國立成功大學 傳染性疾病及訊息研究中心

Center of Infectious Disease and Signaling Research

2018研究成果發表 共86篇

 

登革病毒研究團隊：

林以行老師(1-8)、彭貴春老師(2, 4, 9, 10)、羅玉枝老師(11)、葉才明老師(2, 4, 5, 12, 13)、劉清泉醫師(1-3, 14-17)、何宗憲醫師(2, 17)、王淑鶯老師(3)、張志鵬老師(1, 4, 18)、余佳益研究員(19)、林秋烽老師(7, 20-25)、簡玉雯醫師(9)、萬書彣老師(6, 26)。

 

腸病毒研究團隊：

陳舜華老師(27-30)、王貞仁老師(2, 17, 31-33)、劉清泉醫師(1-3, 14-17)、王世敏醫師(17)、張權發老師(27, 32, 34)、徐麗君老師、王憲威老師。

 

肝炎病毒研究團隊：

黃溫雅老師(33, 35-41)、張定宗醫師(42-48)、楊孔嘉老師(47, 49-52)。

 

腸道菌相及細菌致病研究團隊：

蔡佩珍老師(1, 3, 53-56)、吳俊忠老師(1, 3, 57-61)、陳振暐老師(58, 62)、鄧景浩老師(59, 61, 63)、橋本昌征老師(63-70)、黃一修老師(71, 72)、阮振維老師(73)、吳偉立老師(74-77)。

 

核心平台：

賴明德老師(78-80)、吳尚蓉老師(81-86)。

 

1.    Chen CL, Cheng MH, Kuo CF, Cheng YL, Li MH, Chang CP, et al. Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection. Antimicrob Agents Chemother. 2018;62(6).

2.    Chen HR, Chao CH, Liu CC, Ho TS, Tsai HP, Perng GC, et al. Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability. PLoS Pathog. 2018;14(4):e1007033.

3.    Hsieh CL, Huang HM, Hsieh SY, Zheng PX, Lin YS, Chiang-Ni C, et al. NAD-Glycohydrolase Depletes Intracellular NAD(+) and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells. Front Microbiol. 2018;9:1733.

4.    Lai YC, Chuang YC, Chang CP, Lin YS, Perng GC, Wu HC, et al. Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy. Antiviral Res. 2018;155:28-38.

5.    Lee YR, Kuo SH, Lin CY, Fu PJ, Lin YS, Yeh TM, et al. Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo. Sci Rep. 2018;8(1):489.

6.    Wan SW, Wu-Hsieh BA, Lin YS, Chen WY, Huang Y, Anderson R. The monocyte-macrophage-mast cell axis in dengue pathogenesis. J Biomed Sci. 2018;25(1):77.

7.    Wu YW, Lin CF, Lin YS, Su WC, Chiu WH. Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells. Cell Death Discov. 2018;4:33.

8.    Zainal N, Tan KK, Johari J, Hussein H, Wan Musa WR, Hassan J, et al. Sera of patients with systemic lupus erythematosus cross-neutralizes dengue viruses. Microbiol Immunol. 2018;62(10):659-72.

9.    Chien YW, Liu ZH, Tseng FC, Ho TC, Guo HR, Ko NY, et al. Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays. BMC Infect Dis. 2018;18(1):156.

10.  Songprakhon P, Limjindaporn T, Perng GC, Puttikhunt C, Thaingtamtanha T, Dechtawewat T, et al. Human glucose-regulated protein 78 modulates intracellular production and secretion of nonstructural protein 1 of dengue virus. J Gen Virol. 2018;99(10):1391-406.

11.   Ho SY, Chang BH, Chung CH, Lin YL, Chuang CH, Hsieh PJ, et al. Development of a computational promoter with highly efficient expression in tumors. BMC Cancer. 2018;18(1):480.

12.  Chao CH, Chen HR, Chuang YC, Yeh TM. Macrophage Migration Inhibitory Factor-Induced Autophagy Contributes to Thrombin-Triggered Endothelial Hyperpermeability in Sepsis. Shock. 2018;50(1):103-11.

13.  Chen HR, Lai YC, Yeh TM. Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate. J Biomed Sci. 2018;25(1):58.

14.  Chen LW, Teng CK, Tsai YS, Wang JN, Tu YF, Shen CF, et al. Influenza-associated neurological complications during 2014-2017 in Taiwan. Brain Dev. 2018;40(9):799-806.

15.  Hung TL, Li MC, Wang LR, Liu CC, Li CW, Chen PL, et al. Legionnaires' disease at a medical center in southern Taiwan. J Microbiol Immunol Infect. 2018;51(3):352-8.

16.  Lee HY, Hsieh YC, Liu CC, Huang YC, Chang KY, Chi H, et al. Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules. J Microbiol Immunol Infect. 2018;51(2):199-206.

17.  Wu KW, Wang SM, Shen CF, Ho TS, Wang JR, Liu CC. Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan. J Microbiol Immunol Infect. 2018;51(6):749-55.

18.  Tzeng HT, Su CC, Chang CP, Lai WW, Su WC, Wang YC. Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype. Int J Cancer. 2018;143(7):1753-63.

19.  Kao YT, Lai MMC, Yu CY. How Dengue Virus Circumvents Innate Immunity. Front Immunol. 2018;9:2860.

20.  Feng PH, Chen KY, Huang YC, Luo CS, Wu SM, Chen TT, et al. Bevacizumab Reduces S100A9-Positive MDSCs Linked to Intracranial Control in Patients with EGFR-Mutant Lung Adenocarcinoma. J Thorac Oncol. 2018;13(7):958-67.

21.  Feng PH, Yu CT, Chen KY, Luo CS, Wu SM, Liu CY, et al. S100A9(+) MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: the role of RELB. Oncotarget. 2018;9(7):7631-43.

22.  Feng PH, Yu CT, Chen KY, Luo CS, Wu SM, Liu CY, et al. Correction: S100A9+ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: the role of RELB. Oncotarget. 2018;9(59):31559.

23.  Jhan MK, HuangFu WC, Chen YF, Kao JC, Tsai TT, Ho MR, et al. Anti-TNF-α restricts dengue virus-induced neuropathy. J Leukoc Biol. 2018;104(5):961-8.

24.  Jhan MK, Shen TJ, Tseng PC, Wang YT, Lin CF. Signaling of Macrophage Inflammatory Protein (MIP)-3β Facilitates Dengue Virus-Induced Microglial Cell Migration. Viruses. 2018;10(12).

25.  Kao JC, HuangFu WC, Tsai TT, Ho MR, Jhan MK, Shen TJ, et al. The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR. PLoS Negl Trop Dis. 2018;12(8):e0006715.

26.  Chiu YH, Chen MC, Wan SW. Sodium Hyaluronate/Chitosan Composite Microneedles as a Single-Dose Intradermal Immunization System. Biomacromolecules. 2018;19(6):2278-85.

27.  Chen KR, Yu CK, Kung SH, Chen SH, Chang CF, Ho TC, et al. Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease. Viruses. 2018;10(12).

28.  Lin YW, Wang LC, Lee CK, Chen SH. Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses. Sci Rep. 2018;8(1):12184.

29.  Liu CW, Lee TL, Chen YC, Liang CJ, Wang SH, Lue JH, et al. PM(2.5)-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway. Part Fibre Toxicol. 2018;15(1):4.

30.  Wang HS, Tsai CL, Chang PY, Chao A, Wu RC, Chen SH, et al. Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. PLoS One. 2018;13(1):e0190573.

31.  Lin XT, Hsu NY, Wang JR, Chen NT, Su HJ, Lin MY. Development of an efficient viral aerosol collector for higher sampling flow rate. Environ Sci Pollut Res Int. 2018;25(4):3884-93.

32.  Wang YF, Chang CF, Tsai HP, Chi CY, Su IJ, Wang JR. Glycan-binding preferences and genetic evolution of human seasonal influenza A(H3N2) viruses during 1999-2007 in Taiwan. PLoS One. 2018;13(5):e0196727.

33.  Yen CJ, Ai YL, Tsai HW, Chan SH, Yen CS, Cheng KH, et al. Hepatitis B virus surface gene pre-S(2) mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection. Hepatology. 2018;68(3):815-26.

34.  Lin YP, Lee YL, Hung CY, Chang CF, Chen Y. Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas. PLoS One. 2018;13(10):e0205371.

35.  Cai Y, Li H, Liu M, Pei Y, Zheng J, Zhou J, et al. Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity. Hepatology. 2018;68(1):48-61.

36.  Chang YY, Yen CJ, Chan SH, Chou YW, Lee YP, Bao CY, et al. NEK2 Promotes Hepatoma Metastasis and Serves as Biomarker for High Recurrence Risk after Hepatic Resection. Ann Hepatol. 2018;17(5):843-56.

37.  Huang W, Wang P, Wu Q. A correlation comparison between Altmetric Attention Scores and citations for six PLOS journals. PLoS One. 2018;13(4):e0194962.

38.  Huang WY, Dong H. Coptidis Rhizoma-Contained Traditional Formulae for Insomnia: A Potential to Prevent Diabetes? Chin J Integr Med. 2018;24(10):785-8.

39.  Huang WY, Zou X, Lu FE, Su H, Zhang C, Ren YL, et al. Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats. Curr Med Sci. 2018;38(4):704-13.

40.  Ren Y, Wang D, Lu F, Zou X, Xu L, Wang K, et al. Coptidis Rhizoma inhibits NLRP3 inflammasome activation and alleviates renal damage in early obesity-related glomerulopathy. Phytomedicine. 2018;49:52-65.

41.  Xie T, Li K, Gong X, Jiang R, Huang W, Chen X, et al. Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway. Phytother Res. 2018;32(11):2247-55.

42.  Chang TT, Tsai HW, Ho CH. Fucosyl-Agalactosyl IgG₁ Induces Cholangiocarcinoma Metastasis and Early Recurrence by Activating Tumor-Associated Macrophage. Cancers (Basel). 2018;10(11).

43.  Lin TC, Chiu YC, Chiu HC, Liu WC, Cheng PN, Chen CY, et al. Clinical utility of hepatitis B surface antigen kinetics in treatment-naïve chronic hepatitis B patients during long-term entecavir therapy. World J Gastroenterol. 2018;24(6):725-36.

44.  Liu CJ, Chuang WL, Sheen IS, Wang HY, Chen CY, Tseng KC, et al. Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV. Gastroenterology. 2018;154(4):989-97.

45.  Puoti M, Foster GR, Wang S, Mutimer D, Gane E, Moreno C, et al. High SVR12 with 8-week and 12-week glecaprevir/pibrentasvir therapy: An integrated analysis of HCV genotype 1-6 patients without cirrhosis. J Hepatol. 2018;69(2):293-300.

46.  Tsai HW, Ho CL, Cheng SW, Lin YJ, Chen CC, Cheng PN, et al. Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma. World J Gastroenterol. 2018;24(10):1152-66.

47.  Tsai P, Lin CC, Sun HY, Lee JC, Chang TT, Young KC. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia. J Microbiol Immunol Infect. 2018;51(4):446-55.

48.  Wu IC, Liu WC, Chang TT. Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations. J Biomed Sci. 2018;25(1):51.

49.  Chang CS, Lu YJ, Chang HH, Hsu SH, Kuo PH, Shieh CC, et al. Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity. Obes Res Clin Pract. 2018;12(Suppl 2):49-61.

50.  Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chong LW, et al. Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation. Viruses. 2018;10(2).

51.  Sun HY, Cheng PN, Tseng CY, Tsai WJ, Chiu YC, Young KC. Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut. 2018;67(7):1342-50.

52.  Wu YH, Tseng CK, Lin CK, Wei CK, Lee JC, Young KC. ICR suckling mouse model of Zika virus infection for disease modeling and drug validation. PLoS Negl Trop Dis. 2018;12(10):e0006848.

53.  Chang TL, Liou PS, Cheng PY, Chang HN, Tsai PJ. Borneol and Luteolin from Chrysanthemum morifolium Regulate Ubiquitin Signal Degradation. J Agric Food Chem. 2018;66(31):8280-90.

54.  Hong WE, Hsu IL, Huang SY, Lee CW, Ko H, Tsai PJ, et al. Assembled growth of 3D Fe(3)O(4)@Au nanoparticles for efficient photothermal ablation and SERS detection of microorganisms. J Mater Chem B. 2018;6(36):5689-97.

55.  Hung YP, Tsai PJ, Lee YT, Tang HJ, Lin HJ, Liu HC, et al. Nationwide surveillance of ribotypes and antimicrobial susceptibilities of toxigenic Clostridium difficile isolates with an emphasis on reduced doxycycline and tigecycline susceptibilities among ribotype 078 lineage isolates in Taiwan. Infect Drug Resist. 2018;11:1197-203.

56.  Liu YH, Chang YC, Chen LK, Su PA, Ko WC, Tsai YS, et al. The ATP-P2X(7) Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation. Front Cell Infect Microbiol. 2018;8:84.

57.  Jean SS, Lee WS, Yu KW, Liao CH, Hsu CW, Chang FY, et al. Corrigendum to "Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)" [J Microbiol Immunol Infect 49 (2016) 969-976]. J Microbiol Immunol Infect. 2018;51(3):423-4.

58.  Kao CY, Chen JW, Liu TL, Yan JJ, Wu JJ. Comparative Genomics of Escherichia coli Sequence Type 219 Clones From the Same Patient: Evolution of the IncI1 bla(CMY)-Carrying Plasmid in Vivo. Front Microbiol. 2018;9:1518.

59.  Li HY, Kao CY, Lin WH, Zheng PX, Yan JJ, Wang MC, et al. Characterization of CRISPR-Cas Systems in Clinical Klebsiella pneumoniae Isolates Uncovers Its Potential Association With Antibiotic Susceptibility. Front Microbiol. 2018;9:1595.

60.  Lin WH, Tseng CC, Wu AB, Chang YT, Kuo TH, Chao JY, et al. Clinical and microbiological characteristics of peritoneal dialysis-related peritonitis caused by Escherichia coli in southern Taiwan. Eur J Clin Microbiol Infect Dis. 2018;37(9):1699-707.

61.  Tseng CC, Wang MC, Lin WH, Liao IC, Chen WC, Teng CH, et al. Role of class II P fimbriae and cytokine response in the pathogenesis of Escherichia coli kidney infection in diabetic mice. J Microbiol Immunol Infect. 2018;51(4):492-9.

62.  Kuo CJ, Wang ST, Lin CM, Chiu HC, Huang CR, Lee DY, et al. A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli. Cell Death Dis. 2018;9(3):381.

63.  Hashimoto M, Matsushima H, Suparthana IP, Ogasawara H, Yamamoto H, Teng C, et al. Digestion of peptidoglycan near the cross-link is necessary for the growth of Bacillus subtilis. Microbiology (Reading). 2018;164(3):299-307.

64.  Fujita K, Uchida N, Horimoto K, Hashimoto M, Nakatani K, Moriyoshi K, et al. Two cases of cavitary lung cancer with concomitant chronic infectious disease. Respir Med Case Rep. 2018;24:122-4.

65.  Hashimoto M, Nagatani Y, Oshio Y, Nitta N, Yamashiro T, Tsukagoshi S, et al. Preoperative assessment of pleural adhesion by Four-Dimensional Ultra-Low-Dose Computed Tomography (4D-ULDCT) with Adaptive Iterative Dose Reduction using Three-Dimensional processing (AIDR-3D). Eur J Radiol. 2018;98:179-86.

66.  Kinoshita H, Hashimoto M, Hirayama J, Fujita K, Takeuchi Y, Iwasaki J, et al. Huge Pseudoaneurysm of the Femoral Artery after Internal Fixation of Femoral Trochanteric Fracture. Case Rep Orthop. 2018;2018:3182643.

67.  Kurata T, Nakanishi S, Hashimoto M, Taoka M, Isobe T, Kato JI. Subunit Composition of Ribosome in the yqgF Mutant Is Deficient in pre-16S rRNA Processing of Escherichia coli. J Mol Microbiol Biotechnol. 2018;28(4):179-82.

68.  Nagatani Y, Hashimoto M, Nitta N, Oshio Y, Yamashiro T, Sato S, et al. Continuous quantitative measurement of the main bronchial dimensions and lung density in the lateral position by four-dimensional dynamic-ventilation CT in smokers and COPD patients. Int J Chron Obstruct Pulmon Dis. 2018;13:3845-56.

69.  Ueda D, Matsugane S, Okamoto W, Hashimoto M, Sato T. A Non-Enzymatic Pathway with Superoxide in Intracellular Terpenoid Synthesis. Angew Chem Int Ed Engl. 2018;57(32):10347-51.

70.  Yamada T, Miyashita M, Kasahara J, Tanaka T, Hashimoto M, Yamamoto H. The transmembrane segment of TagH is required for wall teichoic acid transport under heat stress in Bacillus subtilis. Microbiology (Reading). 2018;164(7):935-45.

71.  Chang C, Amer BR, Osipiuk J, McConnell SA, Huang IH, Hsieh V, et al. In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking. Proc Natl Acad Sci U S A. 2018;115(24):E5477-e86.

72.  Hong YP, Wang YW, Huang IH, Liao YC, Kuo HC, Liu YY, et al. Genetic Relationships among Multidrug-Resistant Salmonella enterica Serovar Typhimurium Strains from Humans and Animals. Antimicrob Agents Chemother. 2018;62(5).

73.  Liao KF, Chiu TL, Huang SY, Hsieh TF, Chang SF, Ruan JW, et al. Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition. Cell Physiol Biochem. 2018;48(6):2231-46.

74.  Gou XX, Jin F, Wu WL, Long JH, Li YY, Gong XY, et al. Induction chronomodulated chemotherapy plus radiotherapy for nasopharyngeal carcinoma: A Phase II prospective randomized study. J Cancer Res Ther. 2018;14(7):1613-9.

75.  Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, et al. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Hum Mol Genet. 2018;27(13):2330-43.

76.  Lee YK, Mehrabian P, Boyajian S, Wu WL, Selicha J, Vonderfecht S, et al. The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer. mSphere. 2018;3(6).

77.  Needham BD, Tang W, Wu WL. Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Dev Neurobiol. 2018;78(5):474-99.

78.  Lee KT, Chang CL, Li CY, Song H, Shan YS, Lai MD. The oncogenic role of MST3 in human gastric cancer. Am J Cancer Res. 2018;8(10):2130-9.

79.  Wang SM, Lim SW, Wang YH, Lin HY, Lai MD, Ko CY, et al. Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation. Redox Biol. 2018;16:104-12.

80.  Weng TY, Wu HF, Li CY, Hung YH, Chang YW, Chen YL, et al. Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation. Sci Rep. 2018;8(1):8216.

81.  Chang CK, Wu SR, Chen YC, Lee KJ, Chung NH, Lu YJ, et al. Mutations in VP1 and 5'-UTR affect enterovirus 71 virulence. Sci Rep. 2018;8(1):6688.

82.  Chang CK, Wu SR, Chen YC, Lee KJ, Chung NH, Lu YJ, et al. Author Correction: Mutations in VP1 and 5'-UTR affect enterovirus 71 virulence. Sci Rep. 2018;8(1):8744.

83.  Fan YC, Chen JM, Lin JW, Chen YY, Wu GH, Su KH, et al. Genotype I of Japanese Encephalitis Virus Virus-like Particles Elicit Sterilizing Immunity against Genotype I and III Viral Challenge in Swine. Sci Rep. 2018;8(1):7481.

84.  Liu CC, Wu SC, Wu SR, Lin HY, Guo MS, Yung-Chih Hu A, et al. Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture. Vaccine. 2018;36(22):3134-9.

85.  Shen WF, Galula JU, Liu JH, Liao MY, Huang CH, Wang YC, et al. Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibody. Elife. 2018;7.

86.  Wu SY, Lan SH, Wu SR, Chiu YC, Lin XZ, Su IJ, et al. Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system. Hepatology. 2018;68(1):141-54.