國立成功大學 傳染性疾病及訊息研究中心

Center of Infectious Disease and Signaling Research

2021研究成果發表 共115篇

 

登革病毒研究團隊：

林以行老師 (1-4)、彭貴春老師(5-7)、羅玉枝老師(6, 8-12)、葉才明老師、劉清泉醫師(4, 13-19)、何宗憲醫師(5, 14, 18, 20-23)、王淑鶯老師(4, 24, 25)、張志鵬老師(2, 3, 23, 26, 27)、余佳益研究員(5, 28, 29)、林秋烽老師 (1, 21, 22, 28, 30-42)、簡玉雯醫師(5-7, 43)、萬書彣老師(23, 32)。

 

腸病毒研究團隊：

陳舜華老師(44-48)、王貞仁老師(49-55)、劉清泉醫師(4, 13-19)、王世敏醫師(44, 46)、張權發老師、徐麗君老師(56)、王憲威老師。

 

肝炎病毒研究團隊：

黃溫雅老師(57)、張定宗醫師 (58-69)、楊孔嘉老師(70)。

 

腸道菌相及細菌致病研究團隊：

蔡佩珍老師(2, 4, 71-89)、吳俊忠老師(1, 4, 89-91)、陳振暐老師(18, 75, 89, 92-96)、鄧景浩老師(89-91, 97-99)、橋本昌征老師(90, 91, 97, 100-106)、黃一修老師(75, 77)、阮振維老師(107, 108)、吳偉立老師(109-112)。

 

核心平台：

賴明德老師(113-115)、吳尚蓉老師(1)。

 

1.    Cheng YL, Kuo CF, Lu SL, Omori H, Wu YN, Hsieh CL, et al. Erratum for Cheng et al., "Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy". mBio. 2021;12(4):e0225021.

2.    Davuluri GVN, Chen CC, Chiu YC, Tsai HW, Chiu HC, Chen YL, et al. Autophagy Drives Galectin-1 Secretion From Tumor-Associated Macrophages Facilitating Hepatocellular Carcinoma Progression. Front Cell Dev Biol. 2021;9:741820.

3.    Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. 2021;17(1):1-382.

4.    Tsai WC, Shen CF, Lin YL, Shen FC, Tsai PJ, Wang SY, et al. Emergence of macrolide-resistant Streptococcus pyogenes emm12 in southern Taiwan from 2000 to 2019. J Microbiol Immunol Infect. 2021;54(6):1086-93.

5.    Pan YH, Liao MY, Chien YW, Ho TS, Ko HY, Yang CR, et al. Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country. PLoS Negl Trop Dis. 2021;15(4):e0009312.

6.    Puc I, Ho TC, Yen KL, Vats A, Tsai JJ, Chen PL, et al. Cytokine Signature of Dengue Patients at Different Severity of the Disease. Int J Mol Sci. 2021;22(6).

7.    Vats A, Ho TC, Puc I, Chen YJ, Chang CH, Chien YW, et al. Evidence that hematopoietic stem cells in human umbilical cord blood is infectable by dengue virus: proposing a vertical transmission candidate. Heliyon. 2021;7(4):e06785.

8.    Chiang MY, Cheng HW, Lo YC, Wang WC, Chang SJ, Cheng CH, et al. 4D spatiotemporal modulation of biomolecules distribution in anisotropic corrugated microwrinkles via electrically manipulated microcapsules within hierarchical hydrogel for spinal cord regeneration. Biomaterials. 2021;271:120762.

9.    Chiang MY, Lo YC, Lai YH, Yong YA, Chang SJ, Chen WL, et al. Protein-based soft actuator with high photo-response and easy modulation for anisotropic cell alignment and proliferation in a liquid environment. J Mater Chem B. 2021;9(33):6634-45.

10.  Hong JY, Lin SC, Kuo BJ, Lo YC. Structural and Biochemical Basis for Higher-Order Assembly between A20-Binding Inhibitor of NF-κB 1 (ABIN1) and M1-Linked Ubiquitins. J Mol Biol. 2021;433(18):167116.

11.   Lo YC, Janta P. Balancing Commercialization and Sustainability in Community-Based Tourism Practices - A Qualitative Study of Factors Affecting Elephant Habitat Communities in Northern Thailand. Front Psychol. 2021;12:685426.

12.  Yu JH, Lin HH, Lo YC, Tseng KC, Hsu CH. Is the Travel Bubble under COVID-19 a Feasible Idea or Not? Int J Environ Res Public Health. 2021;18(11).

13.  Hung H, Kueh LL, Tseng CC, Huang HW, Wang SY, Hu YN, et al. Assessing the quality of electronic medical records as a platform for resident education. BMC Med Educ. 2021;21(1):577.

14.  Kuo CY, Tsai WC, Lee HF, Ho TS, Huang LM, Shen CF, et al. The epidemiology, clinical characteristics, and macrolide susceptibility of Mycoplasma pneumoniae pneumonia in children in Southern Taiwan, 2019-2020. J Microbiol Immunol Infect. 2021.

15.  Lin FJ, Huang YC, Huang YC, Huang LM, Liu CC, Chi H, et al. Clinical and epidemiological features in hospitalized young children with acute gastroenteritis in Taiwan: A multicentered surveillance through 2014-2017. J Formos Med Assoc. 2021.

16.  Lin SW, Shen CF, Liu CC, Cheng CM. A Paper-Based IL-6 Test Strip Coupled With a Spectrum-Based Optical Reader for Differentiating Influenza Severity in Children. Front Bioeng Biotechnol. 2021;9:752681.

17.  Lin SW, Shen CF, Liu CC, Cheng CM. Corrigendum: A Paper-Based IL-6 Test Strip Coupled With a Spectrum-Based Optical Reader for Differentiating Influenza Severity in Children. Front Bioeng Biotechnol. 2021;9:802615.

18.  Ouali BEF, Chiou TH, Chen JW, Lin IC, Liu CC, Chiang YC, et al. Correlation Between Pathogenic Determinants Associated with Clinically Isolated Non-Typhoidal Salmonella. Pathogens. 2021;10(1).

19.  Wu CY, Chi H, Liu CC, Huang YC, Huang YC, Lin HC, et al. Clinical characteristics and risk factors for children with norovirus gastroenteritis in Taiwan. J Microbiol Immunol Infect. 2021;54(5):909-17.

20.  Du PX, Chou YY, Santos HM, Keskin BB, Hsieh MH, Ho TS, et al. Development and Application of Human Coronavirus Protein Microarray for Specificity Analysis. Anal Chem. 2021;93(21):7690-8.

21.  Nanda JD, Ho TS, Satria RD, Jhan MK, Wang YT, Lin CF. IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis. J Immunol Res. 2021;2021:8214656.

22.  Nanda JD, Jung CJ, Satria RD, Jhan MK, Shen TJ, Tseng PC, et al. Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression. J Immunol Res. 2021;2021:7652569.

23.  Wan SW, Lee YR, Ho TS, Chang CP. Regulation of innate immune signaling pathways by autophagy in dengue virus infection. IUBMB Life. 2021.

24.  Wei YN, Huang XG, Zeng JQ, Li QQ, Ma LJ, Lei LT, et al. Critical quality attribute assessment of big brand traditional Chinese medicine: study on NIR field detection method of chemical properties of moisture in Tongren Niuhuang Qingxin Pills. Zhongguo Zhong Yao Za Zhi. 2021;46(7):1592-7.

25.  Zeng JQ, Li QQ, Ma LJ, Zhu ML, Mao N, Wu ZF, et al. Critical quality attribute assessment of big brand traditional Chinese medicine: quality control of Tongren Niuhuang Qingxin Pills in texture and sensory attributes. Zhongguo Zhong Yao Za Zhi. 2021;46(7):1598-605.

26.  Kuo IY, Yang YE, Yang PS, Tsai YJ, Tzeng HT, Cheng HC, et al. Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment. Theranostics. 2021;11(14):7029-44.

27.  Kuo WT, Chang JM, Chen CC, Tsao N, Chang CP. Autophagy drives plasticity and functional polarization of tumor-associated macrophages. IUBMB Life. 2021.

28.  Jhan MK, Chen CL, Shen TJ, Tseng PC, Wang YT, Satria RD, et al. Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus. Cells. 2021;10(11).

29.  Wang HI, Chuang ZS, Kao YT, Lin YL, Liang JJ, Liao CC, et al. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants. Int J Mol Sci. 2021;22(16).

30.  Chang CC, Yen YC, Lee CY, Lin CF, Huang CC, Tsai CW, et al. Lower risk of primary Sjogren's syndrome in patients with dengue virus infection: a nationwide cohort study in Taiwan. Clin Rheumatol. 2021;40(2):537-46.

31.  Chang CJ, Lin CF, Chen BC, Lin PY, Chen CL. SHP2: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis. IUBMB Life. 2021.

32.  Chang CJ, Lin CF, Lee CH, Chuang HC, Shih FC, Wan SW, et al. Overcoming interferon (IFN)-γ resistance ameliorates transforming growth factor (TGF)-β-mediated lung fibroblast-to-myofibroblast transition and bleomycin-induced pulmonary fibrosis. Biochem Pharmacol. 2021;183:114356.

33.  Chen CC, Lin YC, Wang ST, Huang CC. Temporal Trends of Acute Kidney Injury and Associated Risk Exposures in Extremely Preterm Infants. Clin J Am Soc Nephrol. 2021;16(8):1169-77.

34.  Hou SK, Lin HA, Chen SC, Lin CF, Lin SF. Monocyte Distribution Width, Neutrophil-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio Improves Early Prediction for Sepsis at the Emergency. J Pers Med. 2021;11(8).

35.  Hsing CH, Tsai CC, Chen CL, Lin YH, Tseng PC, Satria RD, et al. Pharmacologically Inhibiting Glycogen Synthase Kinase-3β Ameliorates Renal Inflammation and Nephrotoxicity in an Animal Model of Cisplatin-Induced Acute Kidney Injury. Biomedicines. 2021;9(8).

36.  Lai CY, Tseng PC, Chen CL, Satria RD, Wang YT, Lin CF. Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages. J Inflamm Res. 2021;14:5241-9.

37.  Putri DU, Chen CL, Wang CH, Sue YM, Tseng PC, Lin CF, et al. Hemodialysis acutely altered interferon-gamma release assay test result and immune cell profile. J Microbiol Immunol Infect. 2021.

38.  Putri DU, Wang CH, Tseng PC, Lee WS, Chen FL, Kuo HP, et al. Profiles of Peripheral Immune Cells of Uncomplicated COVID-19 Cases with Distinct Viral RNA Shedding Periods. Viruses. 2021;13(3).

39.  Satria RD, Huang TW, Jhan MK, Shen TJ, Tseng PC, Wang YT, et al. Increased TNF-α Initiates Cytoplasmic Vacuolization in Whole Blood Coculture with Dengue Virus. J Immunol Res. 2021;2021:6654617.

40.  Shen TJ, Chen CL, Jhan MK, Tseng PC, Satria RD, Hsing CH, et al. Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation. J Immunol Res. 2021;2021:6680913.

41.  Shen TJ, Hanh VT, Nguyen TQ, Jhan MK, Ho MR, Lin CF. Repurposing the Antiemetic Metoclopramide as an Antiviral Against Dengue Virus Infection in Neuronal Cells. Front Cell Infect Microbiol. 2020;10:606743.

42.  Wu SY, Chen YL, Lee YR, Lin CF, Lan SH, Lan KY, et al. The Autophagosomes Containing Dengue Virus Proteins and Full-Length Genomic RNA Are Infectious. Viruses. 2021;13(10).

43.  Hsu YC, Wang JD, Huang PH, Chien YW, Chiu CJ, Lin CY. Integrating domain knowledge with machine learning to detect obstructive sleep apnea: Snore as a significant bio-feature. J Sleep Res. 2021:e13487.

44.  Chen PC, Shao YT, Hsieh MH, Kao HF, Kuo WS, Wang SM, et al. Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained macrophage immunity. Cell Mol Immunol. 2021;18(2):472-83.

45.  Chen SH, Lin YJ, Wang LC, Tsai HY, Yang CH, Teng YT, et al. Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice. Int J Mol Sci. 2021;22(21).

46.  Liao YT, Tsai HP, Wang SM, Chen SH. Clinical and Immune Responses of Peripheral Chemical Sympathectomy in Enterovirus 71 Infection. Front Immunol. 2021;12:700903.

47.  Pakpour AH, Lin CK, Safdari M, Lin CY, Chen SH, Hamilton K. Using an Integrated Social Cognition Model to Explain Green Purchasing Behavior among Adolescents. Int J Environ Res Public Health. 2021;18(23).

48.  Tsai MS, Wang LC, Tsai HY, Lin YJ, Wu HL, Tzeng SF, et al. Microglia Reduce Herpes Simplex Virus 1 Lethality of Mice with Decreased T Cell and Interferon Responses in Brains. Int J Mol Sci. 2021;22(22).

49.  Chang YT, Ling TC, Cheng YY, Sun CY, Wu JL, Tai CH, et al. Comparison of Immunogenicity and Safety between a Single Dose and One Booster Trivalent Inactivated Influenza Vaccination in Patients with Chronic Kidney Disease: A 20-Week, Open-Label Trial. Vaccines (Basel). 2021;9(3).

50.  Cia CT, Lin IT, Lee JC, Tsai HP, Wang JR, Ko WC. Respiratory viral infections in pragmatically selected adults in intensive care units. Sci Rep. 2021;11(1):20058.

51.  Lee YR, Chang CM, Yeh YC, Huang CF, Lin FM, Huang JT, et al. Honeysuckle Aqueous Extracts Induced let-7a Suppress EV71 Replication and Pathogenesis In Vitro and In Vivo and Is Predicted to Inhibit SARS-CoV-2. Viruses. 2021;13(2).

52.  Lin CY, Shih MC, Chang HC, Lin KJ, Chen LF, Huang SW, et al. Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity. J Biomed Sci. 2021;28(1):66.

53.  Lin YL, Lu MY, Chuang CF, Kuo Y, Lin HE, Li FA, et al. TLR7 Is Critical for Anti-Viral Humoral Immunity to EV71 Infection in the Spinal Cord. Front Immunol. 2020;11:614743.

54.  Lu MY, Lin YL, Kuo Y, Chuang CF, Wang JR, Liao F. Muscle Tissue Damage and Recovery After EV71 Infection Correspond to Dynamic Macrophage Phenotypes. Front Immunol. 2021;12:648184.

55.  Sitjar J, Liao JD, Lee H, Tsai HP, Wang JR, Liu PY. Challenges of SERS technology as a non-nucleic acid or -antigen detection method for SARS-CoV-2 virus and its variants. Biosens Bioelectron. 2021;181:113153.

56.  Hsu CY, Lee KT, Sun TY, Sze CI, Huang SS, Hsu LJ, et al. WWOX and Its Binding Proteins in Neurodegeneration. Cells. 2021;10(7).

57.  Gong J, Dong H, Wang DK, Lu FE, Huang ZY, Fang K, et al. Characteristics of Viral Shedding in Respiratory Samples and Specific Antibodies Production in 564 COVID-19 Patients. Curr Med Sci. 2021;41(1):46-50.

58.  Chiu HC, Chiu YC, Yang EH, Chang TT, Chien SC, Wu IC, et al. Effectiveness and safety of ledipasvir/sofosbuvir for genotype 2 chronic hepatitis C infection: Real-world experience from Taiwan. J Formos Med Assoc. 2021;120(3):983-90.

59.  Huang YS, Chang TT, Peng CY, Lo GH, Hsu CW, Hu CT, et al. Herbal and dietary supplement-induced liver injury in Taiwan: comparison with conventional drug-induced liver injury. Hepatol Int. 2021;15(6):1456-65.

60.  Huang YS, Tseng SY, Chen WW, Chang TT, Peng CY, Lo GH, et al. Clinical characteristics and outcomes of drug-induced liver injury in Taiwan with an emphasis on the impact of chronic hepatitis B infection. J Chin Med Assoc. 2021.

61.  Huang YS, Wu CY, Chang TT, Peng CY, Lo GH, Hsu CW, et al. Drug-induced liver injury associated with severe cutaneous adverse drug reactions: A nationwide study in Taiwan. Liver Int. 2021;41(11):2671-80.

62.  Lin SY, Chang TT, Steffen JD, Chen S, Jain S, Song W, et al. Detection of CTNNB1 Hotspot Mutations in Cell-Free DNA from the Urine of Hepatocellular Carcinoma Patients. Diagnostics (Basel). 2021;11(8).

63.  Lin SY, Su YP, Trauger ER, Song BP, Thompson EGC, Hoffman MC, et al. Detection of Hepatitis B Virus-Host Junction Sequences in Urine of Infected Patients. Hepatol Commun. 2021;5(10):1649-59.

64.  Lin SY, Zhang A, Lian J, Wang J, Chang TT, Lin YJ, et al. Recurrent HBV Integration Targets as Potential Drivers in Hepatocellular Carcinoma. Cells. 2021;10(6).

65.  Liu CJ, Sheen IS, Chen CY, Chuang WL, Wang HY, Tseng KC, et al. Ledipasvir/Sofosbuvir for Patients Coinfected With Chronic Hepatitis C and Hepatitis B in Taiwan: Follow-up 108 Weeks Posttreatment. Clin Infect Dis. 2021.

66.  Pan CQ, Chang TT, Bae SH, Brunetto M, Seto WK, Coffin CS, et al. Antiviral kinetics of tenofovir alafenamide and tenofovir disoproxil fumarate over 24 weeks in women of childbearing potential with chronic HBV. PLoS One. 2021;16(5):e0251552.

67.  Teng W, Chang TT, Yang HI, Peng CY, Su CW, Su TH, et al. Risk scores to predict HCC and the benefits of antiviral therapy for CHB patients in gray zone of treatment guidelines. Hepatol Int. 2021;15(6):1421-30.

68.  Tsai HM, Han MZ, Lin YJ, Chang TT, Chen CY, Cheng PN, et al. Real-world outcome of immune checkpoint inhibitors for advanced hepatocellular carcinoma with macrovascular tumor thrombosis. Cancer Immunol Immunother. 2021;70(7):1929-37.

69.  Wu IC, Liu WC, Chiu YC, Chiu HC, Cheng PN, Chang TT. Clinical Implications of Serum Hepatitis B Virus Pregenomic RNA Kinetics in Chronic Hepatitis B Patients Receiving Antiviral Treatment and Those Achieving HBsAg Loss. Microorganisms. 2021;9(6).

70.  Sun HY, Chen TY, Tan YC, Wang CH, Young KC. Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses. Commun Biol. 2021;4(1):564.

71.  Chang WC, Wu HY, Kan HL, Lin YC, Tsai PJ, Chen YC, et al. Discovery of Spoilage Markers for Chicken Eggs Using Liquid Chromatography-High Resolution Mass Spectrometry-Based Untargeted and Targeted Foodomics. J Agric Food Chem. 2021;69(14):4331-41.

72.  Chen JY, Wu YP, Li CY, Jheng HF, Kao LZ, Yang CC, et al. PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity. J Biomed Sci. 2021;28(1):22.

73.  Chiu CW, Tsai PJ, Lee CC, Ko WC, Hung YP. Inhibition of spores to prevent the recurrence of Clostridioides difficile infection - A possibility or an improbability? J Microbiol Immunol Infect. 2021;54(6):1011-7.

74.  Chiu CW, Tsai PJ, Lee CC, Ko WC, Hung YP. Application of Microbiome Management in Therapy for Clostridioides difficile Infections: From Fecal Microbiota Transplantation to Probiotics to Microbiota-Preserving Antimicrobial Agents. Pathogens. 2021;10(6).

75.  Chiu PJ, Rathod J, Hong YP, Tsai PJ, Hung YP, Ko WC, et al. Clostridioides difficile spores stimulate inflammatory cytokine responses and induce cytotoxicity in macrophages. Anaerobe. 2021;70:102381.

76.  Huang A, Lin YS, Kao LZ, Chiou YW, Lee GH, Lin HH, et al. Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity. Clin Transl Med. 2021;11(9):e543.

77.  Hung YP, Chen YF, Tsai PJ, Huang IH, Ko WC, Jan JS. Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases. Pharmaceutics. 2021;13(11).

78.  Hung YP, Lee CC, Lee JC, Tsai PJ, Hsueh PR, Ko WC. The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant Enterobacterales. Antibiotics (Basel). 2021;10(9).

79.  Hung YP, Lee CC, Lee JC, Tsai PJ, Ko WC. Gut Dysbiosis during COVID-19 and Potential Effect of Probiotics. Microorganisms. 2021;9(8).

80.  Hung YP, Lee JC, Tsai BY, Wu JL, Liu HC, Liu HC, et al. Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: Vary by hospitalized duration. J Microbiol Immunol Infect. 2021;54(2):276-83.

81.  Hung YP, Tsai CS, Tsai BY, Tsai PJ, Lee YT, Lee JC, et al. Clostridioides difficile infection in patients with hematological malignancy: A multicenter study in Taiwan. J Microbiol Immunol Infect. 2021;54(6):1101-10.

82.  Lai YH, Tsai BY, Hsu CY, Chen YH, Chou PH, Chen YL, et al. The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients. Front Immunol. 2021;12:691039.

83.  Lai YH, Tsai BY, Hsu CY, Chen YH, Chou PH, Chen YL, et al. Corrigendum: The Role of Toll-Like Receptor-2 in Clostridioides difficile Infection: Evidence From a Mouse Model and Clinical Patients. Front Immunol. 2021;12:803805.

84.  Lee CC, Lee JC, Chiu CW, Tsai PJ, Ko WC, Hung YP. Clinical Significance of Toxigenic Clostridioides difficile Growth in Stool Cultures during the Era of Nonculture Methods for the Diagnosis of C. difficile Infection. Microbiol Spectr. 2021;9(2):e0079921.

85.  Lee JC, Hung YP, Tsai BY, Tsai PJ, Ko WC. Severe Clostridium difficile infections in intensive care units: Diverse clinical presentations. J Microbiol Immunol Infect. 2021;54(6):1111-7.

86.  Shih YH, Tsai PJ, Chen YL, Pranata R, Chen RJ. Assessment of the Antibacterial Mechanism of Pterostilbene against Bacillus cereus through Apoptosis-like Cell Death and Evaluation of Its Beneficial Effects on the Gut Microbiota. J Agric Food Chem. 2021;69(41):12219-29.

87.  Tsai WC, Tsai PJ, Tsai BY, Tsai CS, Chen PL, Lee NY, et al. Community-onset Clostridioides difficile infection in a pregnant woman without traditional risk factors. J Microbiol Immunol Infect. 2021;54(6):1188-9.

88.  Yang CC, Wu CH, Lin TC, Cheng YN, Chang CS, Lee KT, et al. Inhibitory effect of PPARγ on NLRP3 inflammasome activation. Theranostics. 2021;11(5):2424-41.

89.  Yang KY, Kao CY, Su MS, Wang S, Chen YL, Hu ST, et al. Glycosyltransferase Jhp0106 (PseE) contributes to flagellin maturation in Helicobacter pylori. Helicobacter. 2021;26(2):e12787.

90.  Hashimoto M, Mao BH, Chiou CS, Huang WC, Nyoman Putra Dwija IB, Jeng SL, et al. Association between Escherichia coli with NotI-restriction resistance and urinary tract infections. J Microbiol Immunol Infect. 2021.

91.  Huang WC, Wong MY, Wang SH, Hashimoto M, Lin MH, Lee MF, et al. The Ferric Citrate Uptake System Encoded in a Novel bla (CTX-M-3)- and bla (TEM-1)-Harboring Conjugative Plasmid Contributes to the Virulence of Escherichia coli. Front Microbiol. 2021;12:667782.

92.  Cia CT, Chen JW, Su SL, Tsai PF, Shu CY, Ko WC, et al. Severe Lung Infection and Septicemia Caused by Paludibacterium purpuratum-A Case Report and Evaluation of Bacterial Traits. Open Forum Infect Dis. 2021;8(11):ofab501.

93.  Danko D, Bezdan D, Afshin EE, Ahsanuddin S, Bhattacharya C, Butler DJ, et al. A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell. 2021;184(13):3376-93.e17.

94.  Liu TY, Tsai SH, Chen JW, Wang YC, Hu ST, Chen YY. Mab_3083c Is a Homologue of RNase J and Plays a Role in Colony Morphotype, Aggregation, and Sliding Motility of Mycobacterium abscessus. Microorganisms. 2021;9(4).

95.  Wang ST, Kuo CJ, Huang CW, Lee TM, Chen JW, Chen CS. OmpR coordinates the expression of virulence factors of Enterohemorrhagic Escherichia coli in the alimentary tract of Caenorhabditis elegans. Mol Microbiol. 2021;116(1):168-83.

96.  Wang YJ, Chen CH, Chen JW, Lin WC. Commensals Serve as Natural Barriers to Mammalian Cells during Acanthamoeba castellanii Invasion. Microbiol Spectr. 2021;9(3):e0051221.

97.  Hashimoto M, Ma YF, Wang ST, Chen CS, Teng CH. Iron Acquisition of Urinary Tract Infection Escherichia coli Involves Pathogenicity in Caenorhabditis elegans. Microorganisms. 2021;9(2).

98.  Lin WH, Wang MC, Liu PY, Chen PS, Wen LL, Teng CH, et al. Escherichia coli urinary tract infections: Host age-related differences in bacterial virulence factors and antimicrobial susceptibility. J Microbiol Immunol Infect. 2021.

99.  Teng CH, Wu PC, Tang SL, Chen YC, Cheng MF, Huang PC, et al. A Large Spatial Survey of Colistin-Resistant Gene mcr-1-Carrying E. coli in Rivers across Taiwan. Microorganisms. 2021;9(4).

100. Hashimoto M, Sawai S, Oshio M, Yoden M, Takeda K. The risk of footswitch misstep during robot-assisted thoracoscopic surgery: a case report. J Surg Case Rep. 2021;2021(12):rjab292.

101. Hashimoto M, Yoden M, Takeda K, Oshio M, Sawai S. [Experience of Treatment for Pneumothorax with Coronavirus Disease 2019( COVID-19) Pneumonia]. Kyobu Geka. 2021;74(12):992-5.

102. Imakita T, Fujita K, Kanai O, Okamura M, Hashimoto M, Nakatani K, et al. Small cell transformation of non-small cell lung cancer under immunotherapy: Case series and literature review. Thorac Cancer. 2021;12(22):3062-7.

103. Kanai O, Ito T, Saito Z, Yamamoto Y, Fujita K, Okamura M, et al. Effect of cyclooxygenase inhibitor use on immunotherapy efficacy in non-small cell lung cancer. Thorac Cancer. 2021;12(6):949-57.

104. Saito Z, Fujita K, Okamura M, Ito T, Yamamoto Y, Kanai O, et al. Efficacy and safety of immune checkpoint inhibitors in patients with non-small cell lung cancer aged 80 years or older. Cancer Rep (Hoboken). 2021;4(6):e1405.

105. Sato S, Nagatani Y, Hashimoto M, Nitta N, Hanaoka J, Ushio N, et al. Usability of the lateral decubitus position on four-dimensional ultra-low-dose computed tomography for the detection of localized pleural adhesion in the pulmonary apical region. Acta Radiol. 2021;62(4):462-73.

106. Tanji C, Hashimoto M, Furuya T, Saito J, Miyamoto T, Koda M. Sigma 1 receptor agonist cutamesine promotes plasticity of serotonergic boutons in lumbar enlargement in spinal cord injured rats. Neurosci Lett. 2021;759:135971.

107. Chang CS, Liao YC, Huang CT, Lin CM, Cheung CHY, Ruan JW, et al. Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice. Cell Rep. 2021;37(8):110016.

108. Tsai YT, Ruan JW, Chang CS, Ko ML, Chou HC, Lin CC, et al. Proteomic and microbial assessments on the effect of Antrodia cinnamomea in C57BL/6 mice. Arch Biochem Biophys. 2021;713:109058.

109. Chen CL, Xue DX, Chen HH, Liang MZ, Lin DZ, Yu M, et al. Nomograms to Predict Overall and Cancer-Specific Survival in Gastric Signet-Ring Cell Carcinoma. J Surg Res. 2021;266:13-26.

110. Lee YC, Wu WL, Lee CK. How COVID-19 Triggers Our Herding Behavior? Risk Perception, State Anxiety, and Trust. Front Public Health. 2021;9:587439.

111. Wu WL. How Ethical Leadership Promotes Knowledge Sharing: A Social Identity Approach. Front Psychol. 2021;12:727903.

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