國立成功大學 傳染性疾病及訊息研究中心

Center of Infectious Disease and Signaling Research

2019研究成果發表 共70篇

 

登革病毒研究團隊：

林以行老師(1-5)、彭貴春老師(1, 6-10)、羅玉枝老師(11)、葉才明老師(1, 3, 12)、劉清泉醫師(8, 13-16)、何宗憲醫師(8, 13, 16)、王淑鶯老師、張志鵬老師(5, 17, 18)、余佳益研究員(3)、林秋烽老師(2, 4, 5, 19-22)、簡玉雯醫師(6, 7, 9, 10, 23)、萬書彣老師(3, 5)。

 

腸病毒研究團隊：

陳舜華老師(24-26)、王貞仁老師(13, 27-30)、劉清泉醫師(8, 13-16)、王世敏醫師(13, 25)、張權發老師(30-33)、徐麗君老師(34)、王憲威老師。

 

肝炎病毒研究團隊：

黃溫雅老師(35-39)、張定宗醫師(40-45)、楊孔嘉老師(40, 46)。

 

腸道菌相及細菌致病研究團隊：

蔡佩珍老師(1, 47-52)、吳俊忠老師(2, 5, 52-54)、陳振暐老師(47)、鄧景浩老師、橋本昌征老師(55-57)、黃一修老師(47, 58-60)、阮振維老師(61, 62)、吳偉立老師(63-66)。

 

核心平台：

賴明德老師(67, 68)、吳尚蓉老師(2, 69, 70)。

 

1.    Chao CH, Wu WC, Lai YC, Tsai PJ, Perng GC, Lin YS, et al. Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage. PLoS Pathog. 2019;15(4):e1007625.

2.    Cheng YL, Kuo CF, Lu SL, Hiroko O, Wu YN, Hsieh CL, et al. Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy. mBio. 2019;10(5).

3.    Kao YS, Yu CY, Huang HJ, Tien SM, Wang WY, Yang M, et al. Combination of Modified NS1 and NS3 as a Novel Vaccine Strategy against Dengue Virus Infection. J Immunol. 2019;203(7):1909-17.

4.    Tsao N, Kuo CF, Cheng MH, Lin WC, Lin CF, Lin YS. Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection. Sci Rep. 2019;9(1):5371.

5.    Tseng PC, Kuo CF, Cheng MH, Wan SW, Lin CF, Chang CP, et al. HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection. Front Immunol. 2019;10:2147.

6.    Chien YW, Ho TC, Huang PW, Ko NY, Ko WC, Perng GC. Low seroprevalence of Zika virus infection among adults in Southern Taiwan. BMC Infect Dis. 2019;19(1):884.

7.    Chien YW, Huang HM, Ho TC, Tseng FC, Ko NY, Ko WC, et al. Seroepidemiology of dengue virus infection among adults during the ending phase of a severe dengue epidemic in southern Taiwan, 2015. BMC Infect Dis. 2019;19(1):338.

8.    Hsieh CC, Hong MY, Ho TS, Liu CC, Perng GC, Chuang CC. Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly. PLoS Negl Trop Dis. 2019;13(12):e0007974.

9.    Hsu AY, Ho TC, Lai ML, Tan SS, Chen TY, Lee M, et al. Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells. Transfusion. 2019;59(9):2938-51.

10.  Perng GC, Ho TC, Shih HI, Lee CH, Huang PW, Chung CH, et al. Seroprevalence of Zika and Dengue Virus Antibodies among Migrant Workers, Taiwan, 2017. Emerg Infect Dis. 2019;25(4):814-6.

11.   Wang CH, Hung PW, Chiang CW, Lombès M, Chen CH, Lee KH, et al. Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Biochim Biophys Acta Mol Cell Res. 2019;1866(8):1282-97.

12.  Lu LH, Chao CH, Yeh TM. Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage. J Infect. 2019;78(3):178-86.

13.  Shen CF, Wang SM, Wang JR, Hu YS, Ho TS, Liu CC. Comparative study of clinical and epidemiological characteristics of major pediatric adenovirus epidemics in southern Taiwan. BMC Infect Dis. 2019;19(1):681.

14.  Syue LS, Tang HJ, Hung YP, Chen PL, Li CW, Li MC, et al. Bloodstream infections in hospitalized adults with dengue fever: Clinical characteristics and recommended empirical therapy. J Microbiol Immunol Infect. 2019;52(2):225-32.

15.  Wang CY, Chang YH, Huang LM, Chi H, Chiu NC, Chang LY, et al. Effects of influenza vaccine and sun exposure time against laboratory-confirmed influenza hospitalizations among young children during the 2012-13 to 2015-16 influenza seasons. J Microbiol Immunol Infect. 2019;52(6):880-7.

16.  Wu PH, Ho YL, Ho TS, Chang CH, Ye JC, Wang CH, et al. Microbial volatile compounds-induced cytotoxicity in the yeast Saccharomyces cerevisiae: The role of MAPK signaling and proteasome regulatory pathway. Chemosphere. 2019;233:786-95.

17.  Kuthati Y, Goutham Davuluri VN, Yang CP, Chang HC, Chang CP, Wong CS. Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats. J Pain Res. 2019;12:2473-85.

18.  Wang CY, Chang YC, Kuo YL, Lee KT, Chen PS, Cheung CHA, et al. Mutation of the PTCH1 gene predicts recurrence of breast cancer. Sci Rep. 2019;9(1):16359.

19.  Krisnawati DI, Liu YC, Lee YJ, Wang YT, Chen CL, Tseng PC, et al. Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection. Sci Rep. 2019;9(1):5682.

20.  Krisnawati DI, Liu YC, Lee YJ, Wang YT, Chen CL, Tseng PC, et al. Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity. J Immunol Res. 2019;2019:1629258.

21.  Shen TJ, Jhan MK, Kao JC, Ho MR, Tsai TT, Tseng PC, et al. A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease. J Vis Exp. 2019(146).

22.  Wu SY, Chen CL, Tseng PC, Chiu CY, Lin YE, Lin CF. Fractionated ionizing radiation facilitates interferon-γ signaling and anticancer activity in lung adenocarcinoma cells. J Cell Physiol. 2019.

23.  Kuo YH, Chien YW, Chen PR, Feng CL, Li CC, Chien CR. Impact of the interval between neoadjuvant concurrent chemoradiotherapy and esophagectomy in the modern era: a population-based propensity-score-matched retrospective cohort study in Asia. World J Surg Oncol. 2019;17(1):222.

24.  Chen SH, Chao A, Tsai CL, Sue SC, Lin CY, Lee YZ, et al. Utilization of HEPES for Enhancing Protein Transfection into Mammalian Cells. Mol Ther Methods Clin Dev. 2019;13:99-111.

25.  Liao YT, Wang SM, Chen SH. Anti-inflammatory and antiviral effects of minocycline in enterovirus 71 infections. Biomed Pharmacother. 2019;118:109271.

26.  Pu CM, Chen YC, Chen YC, Lee TL, Peng YS, Chen SH, et al. Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps. Mediators Inflamm. 2019;2019:2343867.

27.  Huang SW, Cheng D, Wang JR. Enterovirus A71: virulence, antigenicity, and genetic evolution over the years. J Biomed Sci. 2019;26(1):81.

28.  Huang SW, Hung SJ, Wang JR. Application of deep sequencing methods for inferring viral population diversity. J Virol Methods. 2019;266:95-102.

29.  Shen KM, Sabbavarapu NM, Fu CY, Jan JT, Wang JR, Hung SC, et al. An integrated microfluidic system for rapid detection and multiple subtyping of influenza A viruses by using glycan-coated magnetic beads and RT-PCR. Lab Chip. 2019;19(7):1277-86.

30.  Tsai YH, Huang SW, Hsieh WS, Cheng CK, Chang CF, Wang YF, et al. Enterovirus A71 Containing Codon-Deoptimized VP1 and High-Fidelity Polymerase as Next-Generation Vaccine Candidate. J Virol. 2019;93(13).

31.  Chang SC, Lin WL, Chang YF, Lee CT, Wu JS, Hsu PH, et al. Glycoproteomic identification of novel plasma biomarkers for oral cancer. J Food Drug Anal. 2019;27(2):483-93.

32.  Chuang PK, Hsiao M, Hsu TL, Chang CF, Wu CY, Chen BR, et al. Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer. Proc Natl Acad Sci U S A. 2019;116(9):3518-23.

33.  Yen CL, Liao YC, Chen RF, Huang YF, Chung WC, Lo PC, et al. Targeted Delivery of Curcumin Rescues Endoplasmic Reticulum-Retained Mutant NOX2 Protein and Avoids Leukocyte Apoptosis. J Immunol. 2019;202(12):3394-403.

34.  Chou PY, Lai FJ, Chen YA, Sie YD, Kuo HL, Su WP, et al. Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment. Cell Death Discov. 2019;5:97.

35.  Gong J, Li J, Dong H, Chen G, Qin X, Hu M, et al. Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88. BMC Complement Altern Med. 2019;19(1):314.

36.  Huang W, Meng X, Huang Y, Liu S, Zhu A, Li P, et al. Nitric Oxide and Cyclic Guanosine Monophosphate Signaling Mediates the Antidepressant Effects of Acupuncture in the Rat Model of Chronic Unpredictable Mild Stress. Med Sci Monit. 2019;25:9112-22.

37.  Qin X, Zhao Y, Gong J, Huang W, Su H, Yuan F, et al. Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction. Theranostics. 2019;9(6):1698-713.

38.  Yen CJ, Yang ST, Chen RY, Huang W, Chayama K, Lee MH, et al. Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis. J Biomed Sci. 2019;26(1):44.

39.  Yuan F, Dong H, Gong J, Wang D, Hu M, Huang W, et al. A Systematic Review and Meta-analysis of Randomized Controlled Trials on the Effects of Turmeric and Curcuminoids on Blood Lipids in Adults with Metabolic Diseases. Adv Nutr. 2019;10(5):791-802.

40.  Chang TT, Cheng JH, Tsai HW, Young KC, Hsieh SY, Ho CH. Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas. J Pathol Clin Res. 2019;5(3):199-212.

41.  Chien SC, Chen CY, Cheng PN, Liu YS, Cheng HC, Chuang CH, et al. Combined Transarterial Embolization/Chemoembolization-Based Locoregional Treatment with Sorafenib Prolongs the Survival in Patients with Advanced Hepatocellular Carcinoma and Preserved Liver Function: A Propensity Score Matching Study. Liver Cancer. 2019;8(3):186-202.

42.  Ho CH, Chang TT, Chien RN. Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis. PLoS One. 2019;14(11):e0225482.

43.  Ho CH, Chen SH, Tsai HW, Wu IC, Chang TT. Fully galactosyl-fucosyl-bisected IgG(1) reduces anti-HBV efficacy and liver histological improvement. Antiviral Res. 2019;163:1-10.

44.  Lee YC, Hsieh CC, Chang TT, Li CY. Contrast-Induced Acute Kidney Injury Among Patients With Chronic Kidney Disease Undergoing Imaging Studies: A Meta-Analysis. AJR Am J Roentgenol. 2019;213(4):728-35.

45.  Lin TC, Liu WC, Hsu YH, Lin JJ, Chiu YC, Chiu HC, et al. Insulin Resistance Associated Disorders Pivoting Long-Term Hepatitis B Surface Antigen Decline During Entecavir Therapy. J Clin Med. 2019;8(11).

46.  Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chang HA, et al. Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation. Biomed Res Int. 2019;2019:3102414.

47.  Chen KY, Rathod J, Chiu YC, Chen JW, Tsai PJ, Huang IH. The Transcriptional Regulator Lrp Contributes to Toxin Expression, Sporulation, and Swimming Motility in Clostridium difficile. Front Cell Infect Microbiol. 2019;9:356.

48.  Chen YH, Li TJ, Tsai BY, Chen LK, Lai YH, Li MJ, et al. Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection. Front Microbiol. 2019;10:1141.

49.  Knight DR, Kullin B, Androga GO, Barbut F, Eckert C, Johnson S, et al. Evolutionary and Genomic Insights into Clostridioides difficile Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance. mBio. 2019;10(2).

50.  Lee CW, Wu PC, Hsu IL, Liu TM, Chong WH, Wu CH, et al. New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging. Small. 2019;15(20):e1805086.

51.  Liu YH, Chang YC, Chen LK, Su PA, Ko WC, Tsai YS, et al. Corrigendum: The ATP-P2X(7) Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation. Front Cell Infect Microbiol. 2019;9:260.

52.  Liu YH, Wu PH, Kang CC, Tsai YS, Chou CK, Liang CT, et al. Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF. Front Microbiol. 2019;10:265.

53.  Lai CC, Chen YS, Lee NY, Tang HJ, Lee SS, Lin CF, et al. Susceptibility rates of clinically important bacteria collected from intensive care units against colistin, carbapenems, and other comparative agents: results from Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART). Infect Drug Resist. 2019;12:627-40.

54.  Liao CH, Lee NY, Tang HJ, Lee SS, Lin CF, Lu PL, et al. Antimicrobial activities of ceftazidime-avibactam, ceftolozane-tazobactam, and other agents against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolated from intensive care units in Taiwan: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan in 2016. Infect Drug Resist. 2019;12:545-52.

55.  Hirayama J, Hashimoto M. Percutaneous Endoscopic Diskectomy using an Interlaminar Approach Based on 3D CT/MR Fusion Imaging. J Neurol Surg A Cent Eur Neurosurg. 2019;80(2):88-95.

56.  Matsumoto K, Ohuchi Y, Yata S, Adachi A, Endo M, Takasugi S, et al. Compressed Amplatzer Vascular Plug II Embolization of the Left Subclavian Artery for Thoracic Endovascular Aortic Repair is Efficient and Safety Method Comparable to Conventional Coil Embolization. Yonago Acta Med. 2019;62(1):24-9.

57.  Yamaguchi A, Sakamoto H, Kitamura T, Hashimoto M, Suye SI. Structure retention of proteins interacting electrostatically with TEMPO-oxidized cellulose nanofiber surface. Colloids Surf B Biointerfaces. 2019;183:110392.

58.  Chen JS, Hsu TK, Hsu BM, Chao SC, Huang TY, Ji DD, et al. Swimming Pool-Associated Vittaforma-Like Microsporidia Linked to Microsporidial Keratoconjunctivitis Outbreak, Taiwan. Emerg Infect Dis. 2019;25(11):2100-3.

59.  Rathod J, Jean JS, Jiang WT, Huang IH, Liu BH, Lee YC. Micro-colonization of arsenic-resistant Staphylococcus sp. As-3 on arsenopyrite (FeAsS) drives arsenic mobilization under anoxic sub-surface mimicking conditions. Sci Total Environ. 2019;669:527-39.

60.  Wong TW, Liao SZ, Ko WC, Wu CJ, Wu SB, Chuang YC, et al. Indocyanine Green-Mediated Photodynamic Therapy Reduces Methicillin-Resistant Staphylococcus aureus Drug Resistance. J Clin Med. 2019;8(3).

61.  Chang CS, Ruan JW, Kao CY. An overview of microbiome based strategies on anti-obesity. Kaohsiung J Med Sci. 2019;35(1):7-16.

62.  Lin TC, Hung YP, Ko WC, Ruan JW. Fecal microbiota transplantation for Clostridium difficile infection in Taiwan: Establishment and implementation. J Microbiol Immunol Infect. 2019;52(6):841-50.

63.  Lee YC, Wu WL. Shared Decision Making and Choice for Bariatric Surgery. Int J Environ Res Public Health. 2019;16(24).

64.  Li YY, Jin F, Zhou JJ, Yu F, Duan XF, He XY, et al. Downregulation of the circadian Period family genes is positively correlated with poor head and neck squamous cell carcinoma prognosis. Chronobiol Int. 2019;36(12):1723-32.

65.  Wen SS, Zhang TT, Xue DX, Wu WL, Wang YL, Wang Y, et al. Metabolic reprogramming and its clinical application in thyroid cancer. Oncol Lett. 2019;18(2):1579-84.

66.  Wu WL, Cheng SJ, Lin SH, Chuang YC, Huang EY, Chen CC. The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Front Cell Neurosci. 2019;13:86.

67.  Hsu TI, Chen YJ, Hung CY, Wang YC, Lin SJ, Su WC, et al. Correction: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy. Oncotarget. 2019;10(60):6536-7.

68.  Liu YH, Yeh IJ, Lai MD, Liu KT, Kuo PL, Yen MC. Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells. Cancers (Basel). 2019;11(1).

69.  Huang KJ, Wei YH, Chiu YC, Wu SR, Shieh DB. Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells. Biomater Sci. 2019;7(4):1311-22.

70.  Lin WC, Tsai CY, Huang JM, Wu SR, Chu LJ, Huang KY. Quantitative proteomic analysis and functional characterization of Acanthamoeba castellanii exosome-like vesicles. Parasit Vectors. 2019;12(1):467.